Systems-level modeling of cancer-fibroblast interaction.
Ontology highlight
ABSTRACT:
SUBMITTER: Wadlow RC
PROVIDER: S-EPMC2731225 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Systems-level modeling of cancer-fibroblast interaction.
Wadlow Raymond C RC Wittner Ben S BS Finley S Aidan SA Bergquist Henry H Upadhyay Rabi R Finn Stephen S Loda Massimo M Mahmood Umar U Ramaswamy Sridhar S
PloS one 20090903 9
Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies to target cancer stroma. We have taken a mathematical approach to begin defining these rules by performing the first large-scale quantitative analysis of fibroblast effects on cancer cell proliferation across more than four hundred heterotypic cell line pairings. Systems-le ...[more]
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