Ontology highlight
ABSTRACT:
SUBMITTER: Shimono Y
PROVIDER: S-EPMC2731699 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Shimono Yohei Y Zabala Maider M Cho Robert W RW Lobo Neethan N Dalerba Piero P Qian Dalong D Diehn Maximilian M Liu Huiping H Panula Sarita P SP Chiao Eric E Dirbas Frederick M FM Somlo George G Pera Renee A Reijo RA Lao Kaiqin K Clarke Michael F MF
Cell 20090801 3
Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and nontumorigenic cancer cells. Three clusters, miR-200c-141, miR-200b-200a-429, and miR-183-96-182 were downregulated in human BCSCs, normal human and murine mammary stem/progenitor cells, and embryonal carcinoma cells. Expression of BMI1, a known regulator of stem cell self-renewal, was modulated ...[more]