Dataset Information

Short sleep duration is associated with a blood pressure nondipping pattern in type 1 diabetes: the DIAPASOM study.

ABSTRACT:

Objective

To assess whether nocturnal blood pressure dipping status in type 1 diabetes is correlated with specific sleep characteristics and differences in nocturnal glycemic profiles.

Research design and methods

Twenty type 1 diabetic adult patients underwent sleep studies with simultaneous 24-h ambulatory blood pressure monitoring and continuous nocturnal glucose monitoring.

Results

Altogether, 55% of patients exhibited blunted blood pressure dipping. They did not differ from the dipper group in age, BMI, or systolic (SBP) and diastolic (DBP) blood pressure. Total sleep period (TSP) was higher in the dipper group (497 +/- 30 vs. 407 +/- 44 min for dippers and nondippers, respectively, P < 0.001). TSP was correlated with SBP and DBP day-night differences (r = 0.44 and 0.49, respectively). Periods of nocturnal hypoglycemia (i.e., % of TSP with glycemia <70 mg/dl) were longer in the dipper group (8.1 +/- 10.7 vs. 0.1 +/- 0.4% for dippers and nondippers, respectively, P = 0.02).

Conclusions

Dipping status in type 1 diabetes was associated with longer sleep duration and with hypoglycemia unawareness.

SUBMITTER: Borel AL

PROVIDER: S-EPMC2732145 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Publications

Short sleep duration is associated with a blood pressure nondipping pattern in type 1 diabetes: the DIAPASOM study.

Borel Anne-Laure AL Benhamou Pierre-Yves PY Baguet Jean-Philippe JP Debaty Isabelle I Levy Patrick P Pépin Jean-Louis JL Mallion Jean-Michel JM

Diabetes care 20090619 9

<h4>Objective</h4>To assess whether nocturnal blood pressure dipping status in type 1 diabetes is correlated with specific sleep characteristics and differences in nocturnal glycemic profiles.<h4>Research design and methods</h4>Twenty type 1 diabetic adult patients underwent sleep studies with simultaneous 24-h ambulatory blood pressure monitoring and continuous nocturnal glucose monitoring.<h4>Results</h4>Altogether, 55% of patients exhibited blunted blood pressure dipping. They did not differ ...[more]

PMID: 19542208

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Project description:ImportanceUnderstanding the interplay between sleep duration, dietary habits, and the risk of developing type 2 diabetes (T2D) is crucial for public health and diabetes prevention strategies.ObjectiveTo investigate the associations of type of diet and duration of sleep with the development of T2D.Design, setting, and participantsData derived from the UK Biobank baseline investigation (2006-2010) were analyzed for this cohort study between May 1 and September 30, 2023. The association between sleep duration and healthy dietary patterns with the risk of T2D was investigated during a median (IQR) follow-up of 12.5 (11.8-13.2) years (end of follow-up, September 30, 2021).ExposureFor the analysis, 247 867 participants were categorized into 4 sleep duration groups: normal (7-8 hours per day), mild short (6 hours per day), moderate short (5 hours per day), and extreme short (3-4 hours per day). Their dietary habits were evaluated based on population-specific consumption of red meat, processed meat, fruits, vegetables, and fish, resulting in a healthy diet score ranging from 0 (unhealthiest) to 5 (healthiest).Main outcomes and measuresCox proportional hazards regression analysis was used to calculate hazard ratios (HRs) and 95% CIs for the development of T2D across various sleep duration groups and healthy diet scores.ResultsThe cohort comprised 247 867 participants with a mean [SD] age of 55.9 [8.1] years, of whom 52.3% were female. During the follow-up, 3.2% of participants were diagnosed with T2D based on hospital registry data. Cox regression analysis, adjusted for confounding variables, indicated a significant increase in the risk of T2D among participants with 5 hours or less of daily sleep. Individuals sleeping 5 hours per day exhibited a 1.16 adjusted HR (95% CI, 1.05-1.28), and individuals sleeping 3 to 4 hours per day exhibited a 1.41 adjusted HR (95% CI, 1.19-1.68) compared with individuals with normal sleep duration. Furthermore, individuals with the healthiest dietary patterns had a reduced risk of T2D (HR, 0.75 [95% CI, 0.63-0.88]). The association between short sleep duration and increased risk of T2D persisted even for individuals following a healthy diet, but there was no multiplicative interaction between sleep duration and healthy diet score.Conclusions and relevanceIn this cohort study involving UK residents, habitual short sleep duration was associated with increased risk of developing T2D. This association persisted even among participants who maintained a healthy diet. To validate these findings, further longitudinal studies are needed, incorporating repeated measures of sleep (including objective assessments) and dietary habits.

Dataset Information

Short sleep duration is associated with a blood pressure nondipping pattern in type 1 diabetes: the DIAPASOM study.

Objective

Research design and methods

Results

Conclusions

Publications

Short sleep duration is associated with a blood pressure nondipping pattern in type 1 diabetes: the DIAPASOM study.

Similar Datasets

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