Ontology highlight
ABSTRACT:
SUBMITTER: Berthold CL
PROVIDER: S-EPMC2732831 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Berthold Catrine L CL Wang He H Nordlund Stefan S Högbom Martin M
Proceedings of the National Academy of Sciences of the United States of America 20090812 34
ADP-ribosylation is a ubiquitous regulatory posttranslational modification involved in numerous key processes such as DNA repair, transcription, cell differentiation, apoptosis, and the pathogenic mechanism of certain bacterial toxins. Despite the importance of this reversible process, very little is known about the structure and mechanism of the hydrolases that catalyze removal of the ADP-ribose moiety. In the phototrophic bacterium Rhodospirillum rubrum, dinitrogenase reductase-activating glyc ...[more]