Ontology highlight
ABSTRACT:
SUBMITTER: Yeger-Lotem E
PROVIDER: S-EPMC2733244 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Yeger-Lotem Esti E Riva Laura L Su Linhui Julie LJ Gitler Aaron D AD Cashikar Anil G AG King Oliver D OD Auluck Pavan K PK Geddie Melissa L ML Valastyan Julie S JS Karger David R DR Lindquist Susan S Fraenkel Ernest E
Nature genetics 20090222 3
Cells respond to stimuli by changes in various processes, including signaling pathways and gene expression. Efforts to identify components of these responses increasingly depend on mRNA profiling and genetic library screens. By comparing the results of these two assays across various stimuli, we found that genetic screens tend to identify response regulators, whereas mRNA profiling frequently detects metabolic responses. We developed an integrative approach that bridges the gap between these dat ...[more]