Ontology highlight
ABSTRACT:
SUBMITTER: Reed J
PROVIDER: S-EPMC2733939 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Reed Jason J Troke Joshua J JJ Schmit Joanna J Han Sen S Teitell Michael A MA Gimzewski James K JK
ACS nano 20080501 5
Cancer and many other diseases are characterized by changes in cell morphology, motion, and mechanical rigidity. However, in live cell cytology, stimulus-induced morphologic changes typically take 10-30 min to detect. Here, we employ live-cell interferometry (LCI) to visualize the rapid response of a whole cell to mechanical stimulation, on a time scale of seconds, and we detect cytoskeletal remodeling behavior within 200 s. This behavior involved small, rapid changes in cell content and miniscu ...[more]