Ontology highlight
ABSTRACT:
SUBMITTER: Platt GW
PROVIDER: S-EPMC2734061 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
FEBS letters 20090509 16
Beta(2)-microglobulin (beta(2)m) is a 99-residue protein that aggregates to form amyloid fibrils in dialysis-related amyloidosis. The protein provides a powerful model for exploration of the structural molecular mechanisms of fibril formation from a full-length protein in vitro. Fibrils have been assembled from beta(2)m under both low pH conditions, where the precursor is disordered, and at neutral pH where the protein is initially natively folded. Here we discuss the roles of sequence and struc ...[more]