Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype.
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ABSTRACT:
SUBMITTER: Brennan P
PROVIDER: S-EPMC2734066 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype.
Brennan Paul P McKay James J Moore Lee L Zaridze David D Mukeria Anush A Szeszenia-Dabrowska Neonilia N Lissowska Jolanta J Rudnai Peter P Fabianova Eleonora E Mates Dana D Bencko Vladimir V Foretova Lenka L Janout Vladimir V Chow Wong-Ho WH Rothman Nathaniel N Chabrier Amélie A Gaborieau Valérie V Timpson Nic N Hung Rayjean J RJ Smith George Davey GD
International journal of epidemiology 20090619 4
<h4>Background</h4>Obesity is a risk factor for several cancers although appears to have an inverse association with cancers strongly related to tobacco. Studying obesity is difficult due to numerous biases and confounding.<h4>Methods</h4>To avoid these biases we used a Mendelian randomization approach incorporating an analysis of variants in the FTO gene that are strongly associated with BMI levels among 7000 subjects from a study of lung, kidney and upper-aerodigestive cancer.<h4>Results</h4>T ...[more]
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