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The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies.

ABSTRACT: There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotypes.

SUBMITTER: Horton R

PROVIDER: S-EPMC2734079 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature

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The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies.

Horton R R Coggill P P Miretti M M MM Sambrook J G JG Traherne J A JA Ward R R Sims S S Palmer S S Sehra H H Harrow J J Rogers J J Carrington M M Trowsdale J J Beck S S

Tissue antigens 20061101 5

There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotype ...[more]

PMID: 17092261

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Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution.

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Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates.

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Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.

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Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.

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The favorable role of homozygosity for killer immunoglobulin-like receptor (KIR) A haplotype in patients with advanced-stage classic Hodgkin lymphoma.

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