Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC2734096 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Lu Zhongju Z Jiang Ya-Ping YP Wang Wei W Xu Xin-Hua XH Mathias Richard T RT Entcheva Emilia E Ballou Lisa M LM Cohen Ira S IS Lin Richard Z RZ
Circulation 20090713 4
<h4>Background</h4>Phosphoinositide 3-kinase (PI3K) p110alpha plays a key role in insulin action and tumorigenesis. Myocyte contraction is initiated by an inward Ca(2+) current (I(Ca,L)) through the voltage-dependent L-type Ca(2+) channel (LTCC). The aim of this study was to evaluate whether p110alpha also controls cardiac contractility by regulating the LTCC.<h4>Methods and results</h4>Genetic ablation of p110alpha (also known as Pik3ca), but not p110beta (also known as Pik3cb), in cardiac myoc ...[more]