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Direct synthesis of medium-bridged twisted amides via a transannular cyclization strategy.

ABSTRACT: The sequential RCM to construct a challenging medium-sized ring followed by a transannular cyclization across a medium-sized ring delivers previously unattainable twisted amides from simple acyclic precursors.

SUBMITTER: Szostak M

PROVIDER: S-EPMC2735017 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Direct synthesis of medium-bridged twisted amides via a transannular cyclization strategy.

Szostak Michal M Aubé Jeffrey J

Organic letters 20090901 17

The sequential RCM to construct a challenging medium-sized ring followed by a transannular cyclization across a medium-sized ring delivers previously unattainable twisted amides from simple acyclic precursors. ...[more]

PMID: 19708701

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Stability of medium-bridged twisted amides in aqueous solutions.

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