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Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds.


ABSTRACT: The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.

SUBMITTER: Bovine HapMap Consortium 

PROVIDER: S-EPMC2735092 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds.

Gibbs Richard A RA   Taylor Jeremy F JF   Van Tassell Curtis P CP   Barendse William W   Eversole Kellye A KA   Gill Clare A CA   Green Ronnie D RD   Hamernik Debora L DL   Kappes Steven M SM   Lien Sigbjørn S   Matukumalli Lakshmi K LK   McEwan John C JC   Nazareth Lynne V LV   Schnabel Robert D RD   Weinstock George M GM   Wheeler David A DA   Ajmone-Marsan Paolo P   Boettcher Paul J PJ   Caetano Alexandre R AR   Garcia Jose Fernando JF   Hanotte Olivier O   Mariani Paola P   Skow Loren C LC   Sonstegard Tad S TS   Williams John L JL   Diallo Boubacar B   Hailemariam Lemecha L   Martinez Mario L ML   Morris Chris A CA   Silva Luiz O C LO   Spelman Richard J RJ   Mulatu Woudyalew W   Zhao Keyan K   Abbey Colette A CA   Agaba Morris M   Araujo Flábio R FR   Bunch Rowan J RJ   Burton James J   Gorni Chiara C   Olivier Hanotte H   Harrison Blair E BE   Luff Bill B   Machado Marco A MA   Mwakaya Joel J   Plastow Graham G   Sim Warren W   Smith Timothy T   Thomas Merle B MB   Valentini Alessio A   Williams Paul P   Womack James J   Woolliams John A JA   Liu Yue Y   Qin Xiang X   Worley Kim C KC   Gao Chuan C   Jiang Huaiyang H   Moore Stephen S SS   Ren Yanru Y   Song Xing-Zhi XZ   Bustamante Carlos D CD   Hernandez Ryan D RD   Muzny Donna M DM   Patil Shobha S   San Lucas Anthony A   Fu Qing Q   Kent Matthew P MP   Vega Richard R   Matukumalli Aruna A   McWilliam Sean S   Sclep Gert G   Bryc Katarzyna K   Choi Jungwoo J   Gao Hong H   Grefenstette John J JJ   Murdoch Brenda B   Stella Alessandra A   Villa-Angulo Rafael R   Wright Mark M   Aerts Jan J   Jann Oliver O   Negrini Riccardo R   Goddard Mike E ME   Hayes Ben J BJ   Bradley Daniel G DG   Barbosa da Silva Marcos M   Lau Lilian P L LP   Liu George E GE   Lynn David J DJ   Panzitta Francesca F   Dodds Ken G KG  

Science (New York, N.Y.) 20090401 5926


The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effec  ...[more]

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