Ontology highlight
ABSTRACT:
SUBMITTER: Roques C
PROVIDER: S-EPMC2735166 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Roques Céline C Coulombe Yan Y Delannoy Mathieu M Vignard Julien J Grossi Simona S Brodeur Isabelle I Rodrigue Amélie A Gautier Jean J Stasiak Alicja Z AZ Stasiak Andrzej A Constantinou Angelos A Masson Jean-Yves JY
The EMBO journal 20090716 16
Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. It was reported earlier that FANCD2 co-localizes with NBS1. However, the functional connection between FANCD2 and MRE11 is poorly understood. In this study, we show that inhibition of MRE11, NBS1 or RAD50 leads to a destabilization of FANCD2. FANCD2 accumulated from mid-S to G2 phase within sites containing single-stranded DNA (ssDNA) intermediates, or at sites of DNA damage, suc ...[more]