Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications.
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ABSTRACT:
SUBMITTER: Godula K
PROVIDER: S-EPMC2735190 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications.
Godula Kamil K Rabuka David D Nam Ki Tae KT Bertozzi Carolyn R CR
Angewandte Chemie (International ed. in English) 20090101 27
Click to view: Glycopolymers can be used to display glycans on microarrays in native-like architectures. The structurally uniform alkyne-terminated mucin mimetic glycopolymers (see picture; TR = fluorophore) were printed on azide-functionalized chips by microcontact printing in the presence of a copper catalyst. The surface-bound glycopolymers bind lectins in a ligand-specific manner. ...[more]
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