Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell-Jordan SA
PROVIDER: S-EPMC2735252 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Mitchell-Jordan Scherise A SA Holopainen Tanja T Ren Shuxun S Wang Sujing S Warburton Sarah S Zhang Michael J MJ Alitalo Kari K Wang Yibin Y Vondriska Thomas M TM
Circulation research 20081106 12
Bmx nonreceptor tyrosine kinase has an established role in endothelial and lymphocyte signaling; however, its role in the heart is unknown. To determine whether Bmx participates in cardiac growth, we subjected mice deficient in the molecule (Bmx knockout mice) to transverse aortic constriction (TAC). In comparison with wild-type mice, which progressively developed massive hypertrophy following TAC, Bmx knockout mice were resistant to TAC-induced cardiac growth at the organ and cell level. Loss o ...[more]