Ontology highlight
ABSTRACT:
SUBMITTER: Kopein D
PROVIDER: S-EPMC2735485 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Kopein Damir D Katanaev Vladimir L VL
Molecular biology of the cell 20090701 17
G protein-coupled receptors (GPCRs) transduce their signals through trimeric G proteins, inducing guanine nucleotide exchange on their Galpha-subunits; the resulting Galpha-GTP transmits the signal further inside the cell. GoLoco domains present in many proteins play important roles in multiple trimeric G protein-dependent activities, physically binding Galpha-subunits of the Galpha(i/o) class. In most cases GoLoco binds exclusively to the GDP-loaded form of the Galpha-subunits. Here we demonstr ...[more]