Ontology highlight
ABSTRACT:
SUBMITTER: Law AL
PROVIDER: S-EPMC2735488 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Law Ah-Lai AL Ling Qi Q Hajjar Katherine A KA Futter Clare E CE Greenwood John J Adamson Peter P Wavre-Shapton Silène T ST Moss Stephen E SE Hayes Matthew J MJ
Molecular biology of the cell 20090708 17
The daily phagocytosis of shed photoreceptor outer segments by pigment epithelial cells is critical for the maintenance of the retina. In a subtractive polymerase chain reaction analysis, we found that functional differentiation of human ARPE19 retinal pigment epithelial (RPE) cells is accompanied by up-regulation of annexin (anx) A2, a major Src substrate and regulator of membrane-cytoskeleton dynamics. Here, we show that anx A2 is recruited to the nascent phagocytic cup in vitro and in vivo an ...[more]