A vital role for interleukin-21 in the control of a chronic viral infection.
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ABSTRACT:
SUBMITTER: Yi JS
PROVIDER: S-EPMC2736049 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
A vital role for interleukin-21 in the control of a chronic viral infection.
Yi John S JS Du Ming M Zajac Allan J AJ
Science (New York, N.Y.) 20090514 5934
Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to prevent or combat infections. In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+ T cells that produce IL-21 differs markedly between acute and chronic infections. IL-21 regulates the development of CD8+ T cell exhau ...[more]
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