Ontology highlight
ABSTRACT:
SUBMITTER: Oyoshi MK
PROVIDER: S-EPMC2736417 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Oyoshi Michiko K MK Elkhal Abdallah A Kumar Lalit L Scott Jordan E JE Koduru Suresh S He Rui R Leung Donald Y M DY Howell Michael D MD Oettgen Hans C HC Murphy George F GF Geha Raif S RS
Proceedings of the National Academy of Sciences of the United States of America 20090817 35
Eczema vaccinatum (EV) is a complication of smallpox vaccination occurring in patients with atopic dermatitis. In affected individuals, vaccinia virus (VV) spreads through the skin, resulting in large primary lesions and satellite lesions, and infects internal organs. BALB/c mice inoculated with VV at sites of Th2-biased allergic skin inflammation elicited by epicutaneous ovalbumin (OVA) sensitization exhibited larger primary lesions that were erosive, more satellite lesions, and higher viral lo ...[more]