Ontology highlight
ABSTRACT:
SUBMITTER: Dreieicher E
PROVIDER: S-EPMC2736775 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Dreieicher Ellen E Beck Karl-Friedrich KF Lazaroski Sandra S Boosen Meike M Tsalastra-Greul Wasiliki W Beck Martina M Fleming Ingrid I Schaefer Liliana L Pfeilschifter Josef J
Journal of the American Society of Nephrology : JASN 20090702 9
Cytokines and nitric oxide (NO) stimulate rat mesangial cells to synthesize and secrete inflammatory mediators. To understand better the signaling pathways that contribute to this response, we exposed rat mesangial cells to the prototypic inflammatory cytokine IL-1beta and analyzed the changes in the pattern of gene expression. IL-1beta downregulated the gene encoding the matricellular glycoprotein secreted modular calcium-binding protein 1 (SMOC-1) in mesangial cells. Inflammatory cytokines att ...[more]