Ontology highlight
ABSTRACT:
SUBMITTER: Wilcox DM
PROVIDER: S-EPMC2737213 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Wilcox Denise M DM Yang Ruojing R Morgan Sherry J SJ Nguyen Phong T PT Voorbach Martin J MJ Jung Paul M PM Haasch Deanna L DL Lin Emily E Bush Eugene N EN Opgenorth Terry J TJ Jacobson Peer B PB Collins Christine A CA Rondinone Cristina M CM Surowy Terry T Landschulz Katherine T KT
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 20061129 1
RNA interference (RNAi) is an exciting new tool to effect acute in vivo knockdown of genes for pharmacological target validation. Testing the application of this technology to metabolic disease targets, three RNAi delivery methods were compared in two frequently utilized preclinical models of obesity and diabetes, the diet-induced obese (DIO) and B6.V-Lep<ob>/J (ob/ob) mouse. Intraperitoneal (i.p.) and high pressure hydrodynamic intravenous (i.v.) administration of naked siRNA, and low pressure ...[more]