Low-renin hypertension with relative aldosterone excess is associated with impaired NO-mediated vasodilation.

ABSTRACT: Recent studies suggest that hypertension associated with low renin status and hyperaldosteronism is associated with increased risk for end-organ damage and cardiovascular events compared with other forms of hypertension. Additionally, experimental studies have demonstrated impaired nitric oxide-mediated bioactivity in these states. To investigate the relation between renin/aldosterone status and resistance vessel function, we examined plasma renin activity, serum aldosterone level, and forearm blood flow responses to the endothelium-dependent vasodilator methacholine and the endothelium-independent vasodilators sodium nitroprusside and verapamil using venous occlusion plethysmography in 130 volunteers (43 hypertensive, 87 normotensive). Low renin status was associated with impaired respons

SUBMITTER: Duffy SJ 

PROVIDER: S-EPMC2737344 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature