Host-parasite interactions revealed by Plasmodium falciparum metabolomics.
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ABSTRACT:
SUBMITTER: Olszewski KL
PROVIDER: S-EPMC2737466 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Host-parasite interactions revealed by Plasmodium falciparum metabolomics.
Olszewski Kellen L KL Morrisey Joanne M JM Wilinski Daniel D Burns James M JM Vaidya Akhil B AB Rabinowitz Joshua D JD Llinás Manuel M
Cell host & microbe 20090201 2
Intracellular pathogens have devised mechanisms to exploit their host cells to ensure their survival and replication. The malaria parasite Plasmodium falciparum relies on an exchange of metabolites with the host for proliferation. Here we describe a mass spectrometry-based metabolomic analysis of the parasite throughout its 48 hr intraerythrocytic developmental cycle. Our results reveal a general modulation of metabolite levels by the parasite, with numerous metabolites varying in phase with the ...[more]
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