Ontology highlight
ABSTRACT:
SUBMITTER: Yap OW
PROVIDER: S-EPMC2737468 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Yap Oi Wah Stephanie OW Bhat Ganapathy G Liu Liang L Tollefsbol Trygve O TO
Anticancer research 20090101 1
<h4>Background</h4>The mechanisms of estrogen insensitivity or estrogen resistance in ovarian cancer cells are not known. Studies on regulation of the estrogen receptor (ER) gene have suggested a role for epigenetics in silencing ER expression.<h4>Materials and methods</h4>Cells from insensitive ovarian cancer cells, SKOV3 and HEY, were cultured with and without the DNA methyltransferase (DNMT) inhibitor, 5-aza-2'-deoxycytidine (AzaC) and the histone deacetylase (HDAC) inhibitor, trichostatin (T ...[more]