Ontology highlight
ABSTRACT:
SUBMITTER: Le LQ
PROVIDER: S-EPMC2737469 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Le Lu Q LQ Shipman Tracey T Burns Dennis K DK Parada Luis F LF
Cell stem cell 20090501 5
The tumor predisposition disorder neurofibromatosis type I (NF1) is one of the most common genetic disorders of the nervous system. It is caused by mutations in the Nf1 tumor-suppressor gene, which encodes a GTPase-activating protein (GAP) that negatively regulates p21-RAS. Development of malignant nerve tumors and neurofibromas occurs frequently in NF1. However, little is known about the molecular mechanisms mediating the initiation and progression of these complex tumors, or the identity of th ...[more]