Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.
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ABSTRACT:
SUBMITTER: Bateup HS
PROVIDER: S-EPMC2737705 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.
Bateup Helen S HS Svenningsson Per P Kuroiwa Mahomi M Gong Shiaoching S Nishi Akinori A Heintz Nathaniel N Greengard Paul P
Nature neuroscience 20080711 8
DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs; however, these drugs are known to have opposing behavioral and clinical effects. We hypothesized that these drugs exert differential effects on striatonigral and striatopallidal neurons, which comprise distinct output pathways of the basal ganglia. To directl ...[more]
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