Ontology highlight
ABSTRACT:
SUBMITTER: Bateup HS
PROVIDER: S-EPMC2737705 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Nature neuroscience 20080711 8
DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs; however, these drugs are known to have opposing behavioral and clinical effects. We hypothesized that these drugs exert differential effects on striatonigral and striatopallidal neurons, which comprise distinct output pathways of the basal ganglia. To directl ...[more]