Ontology highlight
ABSTRACT:
SUBMITTER: Newberg LA
PROVIDER: S-EPMC2737730 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Journal of computational biology : a journal of computational molecular cell biology 20081101 9
Measurement of the the statistical significance of extreme sequence alignment scores is key to many important applications, but it is difficult. To precisely approximate alignment score significance, we draw random samples directly from a well chosen, importance-sampling probability distribution. We apply our technique to pairwise local sequence alignment of nucleic acid and amino acid sequences of length up to 1000. For instance, using a BLOSUM62 scoring system for local sequence alignment, we ...[more]