Ontology highlight
ABSTRACT:
SUBMITTER: Zhang N
PROVIDER: S-EPMC2737741 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Zhang Nan N Schröppel Bernd B Lal Girdhari G Jakubzick Claudia C Mao Xia X Chen Dan D Yin Na N Jessberger Rolf R Ochando Jordi C JC Ding Yaozhong Y Bromberg Jonathan S JS
Immunity 20090301 3
To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands. In the allograft, Treg cells were activated and subsequently migrated to the draining lymph nodes (dLNs) in a CCR ...[more]