Ontology highlight
ABSTRACT:
SUBMITTER: Kitamura A
PROVIDER: S-EPMC2737848 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Kitamura Akihiro A Higuchi Saito S Hata Masato M Kawakami Katsuhiro K Yoshida Kumi K Namba Kenji K Nakajima Ryohei R
Antimicrobial agents and chemotherapy 20090713 9
Beta-1,6-glucan is a fungus-specific cell wall component that is essential for the retention of many cell wall proteins. We recently reported the discovery of a small molecule inhibitor of beta-1,6-glucan biosynthesis in yeasts. In the course of our study of its derivatives, we found a unique feature in their antifungal profile. D21-6076, one of these compounds, exhibited potent in vitro and in vivo antifungal activities against Candida glabrata. Interestingly, although it only weakly reduced th ...[more]