Ontology highlight
ABSTRACT:
SUBMITTER: Ibrahim HM
PROVIDER: S-EPMC2737997 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Ibrahim Hany M HM Bannai Hiroshi H Xuan Xuenan X Nishikawa Yoshifumi Y
Infection and immunity 20090629 9
Toxoplasma gondii modulates pro- and anti-inflammatory responses to regulate parasite multiplication and host survival. Pressure from the immune response causes the conversion of tachyzoites into slowly dividing bradyzoites. The regulatory mechanisms involved in this switch are poorly understood. The aim of this study was to investigate the immunomodulatory role of T. gondii cyclophilin 18 (TgCyp18) in macrophages and the consequences of the cellular responses on the conversion machinery. Recomb ...[more]