Ontology highlight
ABSTRACT:
SUBMITTER: Sharon H
PROVIDER: S-EPMC2738002 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Sharon Haim H Hagag Shelly S Osherov Nir N
Infection and immunity 20090629 9
The role of secreted proteases in the virulence of the pathogenic fungus Aspergillus fumigatus remains controversial. Recently, the Aspergillus niger transcription factor PrtT was shown to control the expression of multiple secreted proteases. In this work, the gene which encodes the PrtT homolog in A. fumigatus was cloned and its function analyzed using a deletion mutant strain. Deletion of A. fumigatus prtT resulted in the loss of secreted protease activity. The expression of six secreted prot ...[more]