Ontology highlight
ABSTRACT:
SUBMITTER: Marcos-Villar L
PROVIDER: S-EPMC2738140 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Marcos-Villar Laura L Lopitz-Otsoa Fernando F Gallego Pedro P Muñoz-Fontela Cesar C González-Santamaría José J Campagna Michela M Shou-Jiang Gao G Rodriguez Manuel S MS Rivas Carmen C
Journal of virology 20090624 17
Infection by herpesviruses causes a dramatic disturbance of PML oncogenic domains (PODs) that has been suggested to be essential for viral lytic replication. Several proteins from Kaposi's sarcoma-associated herpesvirus (KSHV) have been tested as putative POD-disrupting factors with negative results. Here, we show that LANA2, a viral protein that is absolutely required for the viability and proliferation of KSHV-infected primary effusion lymphoma (PEL) cells, increases the levels of SUMO2-ubiqui ...[more]