Ontology highlight
ABSTRACT:
SUBMITTER: Loh ML
PROVIDER: S-EPMC2738571 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Blood 20090701 9
Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Seventy-five percent of patients harbor mutations in the NF1, NRAS, KRAS, or PTPN11 genes, which encode components of Ras signaling networks. Using single nucleotide polymorphism arrays, we identified a region of 11q isodisomy that contains the CBL gene in several JMML samples, and subseque ...[more]