Ontology highlight
ABSTRACT:
SUBMITTER: Bennett LB
PROVIDER: S-EPMC2738630 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Bennett Lynda B LB Schnabel Jennifer L JL Kelchen Jean M JM Taylor Kristen H KH Guo Juyuan J Arthur Gerald L GL Papageorgio Christos N CN Shi Huidong H Caldwell Charles W CW
Genes, chromosomes & cancer 20090901 9
High-throughput microarray technologies were used to study DNA methylation accompanied by transcriptional changes in follicular lymphoma (FL). Using Methylated CpG Island Amplification with Microarrays to study CpG Island DNA methylation in FL, we discovered widespread hypermethylation of homeobox genes and previously identified targets of polycomb repressive complex 2 (PRC2) in cell lines and primary tumors, but not in benign follicular hyperplasia (BFH). DNA methylation for HOXA11, HOXD10, HOX ...[more]