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Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome.

ABSTRACT: The proinflammatory cytokine IL-1beta plays an important role in antifungal immunity; however, the mechanisms by which fungal pathogens trigger IL-1beta secretion are unclear. In this study we show that infection with Candida albicans is sensed by the Nlrp3 inflammasome, resulting in the subsequent release of IL-1beta. The ability of C. albicans to switch from a unicellular yeast form into a filamentous form is essential for activation of the Nlrp3 inflammasome, as C. albicans mutants incapable of forming hyphae were defective in their ability to induce macrophage IL- 1beta secretion. Nlrp3-deficient mice also demonstrated increased susceptibility to infection with C. albicans, which is consistent with a key role for Nlrp3 in innate immune responses to the pathogen C. albicans.

SUBMITTER: Joly S

PROVIDER: S-EPMC2739101 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome.

Joly Sophie S Ma Ning N Sadler Jeffrey J JJ Soll David R DR Cassel Suzanne L SL Sutterwala Fayyaz S FS

Journal of immunology (Baltimore, Md. : 1950) 20090814 6

The proinflammatory cytokine IL-1beta plays an important role in antifungal immunity; however, the mechanisms by which fungal pathogens trigger IL-1beta secretion are unclear. In this study we show that infection with Candida albicans is sensed by the Nlrp3 inflammasome, resulting in the subsequent release of IL-1beta. The ability of C. albicans to switch from a unicellular yeast form into a filamentous form is essential for activation of the Nlrp3 inflammasome, as C. albicans mutants incapable ...[more]

PMID: 19684085

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