Does negative auto-regulation increase gene duplicability?
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ABSTRACT:
SUBMITTER: Warnecke T
PROVIDER: S-EPMC2739200 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Does negative auto-regulation increase gene duplicability?
Warnecke Tobias T Wang Guang-Zhong GZ Lercher Martin J MJ Hurst Laurence D LD
BMC evolutionary biology 20090807
<h4>Background</h4>A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases where the level of gene product is controlled, via negative feedback, by its own abundance, an increase in gene copy number can in principle be decoupled from an increase in protein while both copies ...[more]
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