Ontology highlight
ABSTRACT:
SUBMITTER: Kussius CL
PROVIDER: S-EPMC2739723 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Kussius Cassandra L CL Popescu Gabriela K GK
Nature neuroscience 20090802 9
Activation of ligand-gated channels is initiated by the binding of small molecules at extracellular sites and culminates with the opening of a membrane-embedded pore. To investigate how perturbations at ligand-binding domains influence the gating reaction, we examined current traces recorded from individual NMDA receptors in the presence of several subunit-specific partial agonists. We found that low-efficacy agonists acting at either the glycine-binding or the glutamate-binding NMDA receptor su ...[more]