Ontology highlight
ABSTRACT:
SUBMITTER: Zeng FY
PROVIDER: S-EPMC2739888 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Zeng Fu-Yue FY Cui Jimmy J Liu Lingling L Chen Taosheng T
Cancer letters 20090512 2
Patients with alveolar rhabdomyosarcoma (ARMS) have poorer response to conventional chemotherapy and lower survival rates than those with embryonal RMS (ERMS). By high-throughput screening, we identified camptothecin as an ARMS-selective inhibitor. Camptothecin more efficiently inhibited proliferation and induced apoptosis in Rh30 (ARMS) than RD (ERMS) cells. Ectopic expression of the PAX3-FKHR (PF) fusion protein in RD cells significantly increased sensitivity, whereas siRNA knockdown of PF dec ...[more]