Gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Serneels L
PROVIDER: S-EPMC2740474 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Serneels Lutgarde L Van Biervliet Jérôme J Craessaerts Katleen K Dejaegere Tim T Horré Katrien K Van Houtvin Tine T Esselmann Hermann H Paul Sabine S Schäfer Martin K MK Berezovska Oksana O Hyman Bradley T BT Sprangers Ben B Sciot Raf R Moons Lieve L Jucker Mathias M Yang Zhixiang Z May Patrick C PC Karran Eric E Wiltfang Jens J D'Hooge Rudi R De Strooper Bart B
Science (New York, N.Y.) 20090319 5927
The gamma-secretase complex plays a role in Alzheimer's disease and cancer progression. The development of clinically useful inhibitors, however, is complicated by the role of the gamma-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins. Different gamma-secretase complexes containing different Presenilin or Aph1 protein subunits are present in various tissues. Here we show that these complexes have heterogeneous biochemical and physiological properties ...[more]
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