Ontology highlight
ABSTRACT:
SUBMITTER: Walmacq C
PROVIDER: S-EPMC2740586 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Walmacq Celine C Kireeva Maria L ML Irvin Jordan J Nedialkov Yuri Y Lubkowska Lucyna L Malagon Francisco F Strathern Jeffrey N JN Kashlev Mikhail M
The Journal of biological chemistry 20090513 29
Rpb9 is a small non-essential subunit of yeast RNA polymerase II located on the surface on the enzyme. Deletion of the RPB9 gene shows synthetic lethality with the low fidelity rpb1-E1103G mutation localized in the trigger loop, a mobile element of the catalytic Rpb1 subunit, which has been shown to control transcription fidelity. Similar to the rpb1-E1103G mutation, the RPB9 deletion substantially enhances NTP misincorporation and increases the rate of mismatch extension with the next cognate N ...[more]