Ontology highlight
ABSTRACT:
SUBMITTER: Seibold MA
PROVIDER: S-EPMC2740590 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Seibold Max A MA Reese Tiffany A TA Choudhry Shweta S Salam Muhammad T MT Beckman Kenny K Eng Celeste C Atakilit Amha A Meade Kelley K Lenoir Michael M Watson H Geoffrey HG Thyne Shannon S Kumar Rajesh R Weiss Kevin B KB Grammer Leslie C LC Avila Pedro P Schleimer Robert P RP Fahy John V JV Rodriguez-Santana Jose J Rodriguez-Cintron William W Boot Rolf G RG Sheppard Dean D Gilliland Frank D FD Locksley Richard M RM Burchard Esteban G EG
The Journal of biological chemistry 20090512 29
Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation. However, little is known regarding genetic regulation of AMCase enzymatic activity in human allergic diseases. Resequencing the AMCase gene exons we identified 8 non-synonymous single nucleotide polymorphisms including three novel variants (A290G, G296A, G339T) near the gene area coding for the enzyme active site, all in linkage disequilibrium. AMCase protein is ...[more]