Representation of internal models of action in the autistic brain.
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ABSTRACT:
SUBMITTER: Haswell CC
PROVIDER: S-EPMC2740616 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Representation of internal models of action in the autistic brain.
Haswell Courtney C CC Izawa Jun J Dowell Lauren R LR Mostofsky Stewart H SH Shadmehr Reza R
Nature neuroscience 20090705 8
Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, ...[more]
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