A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
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ABSTRACT:
SUBMITTER: Gudbjartsson DF
PROVIDER: S-EPMC2740741 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
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A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
Gudbjartsson Daniel F DF Holm Hilma H Gretarsdottir Solveig S Thorleifsson Gudmar G Walters G Bragi GB Thorgeirsson Gudmundur G Gulcher Jeffrey J Mathiesen Ellisiv B EB Njølstad Inger I Nyrnes Audhild A Wilsgaard Tom T Hald Erin M EM Hveem Kristian K Stoltenberg Camilla C Kucera Gayle G Stubblefield Tanya T Carter Shannon S Roden Dan D Ng Maggie C Y MC Baum Larry L So Wing Yee WY Wong Ka Sing KS Chan Juliana C N JC Gieger Christian C Wichmann H-Erich HE Gschwendtner Andreas A Dichgans Martin M Kuhlenbäumer Gregor G Berger Klaus K Ringelstein E Bernd EB Bevan Steve S Markus Hugh S HS Kostulas Konstantinos K Hillert Jan J Sveinbjörnsdóttir Sigurlaug S Valdimarsson Einar M EM Løchen Maja-Lisa ML Ma Ronald C W RC Darbar Dawood D Kong Augustine A Arnar David O DO Thorsteinsdottir Unnur U Stefansson Kari K
Nature genetics 20090713 8
We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) ...[more]
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