Ontology highlight
ABSTRACT:
SUBMITTER: Garrett WS
PROVIDER: S-EPMC2740755 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Garrett Wendy S WS Punit Shivesh S Gallini Carey A CA Michaud Monia M Zhang Dorothy D Sigrist Kirsten S KS Lord Graham M GM Glickman Jonathan N JN Glimcher Laurie H LH
Cancer cell 20090901 3
We previously described a mouse model of ulcerative colitis linked to T-bet deficiency in the innate immune system. Here, we report that the majority of T-bet(-/-)RAG2(-/-) ulcerative colitis (TRUC) mice spontaneously progress to colonic dysplasia and rectal adenocarcinoma solely as a consequence of MyD88-independent intestinal inflammation. Dendritic cells (DCs) are necessary cellular effectors for a proinflammatory program that is carcinogenic. Whereas these malignancies arise in the setting o ...[more]