Ontology highlight
ABSTRACT:
SUBMITTER: Colon-Ramos DA
PROVIDER: S-EPMC2741089 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Colón-Ramos Daniel A DA Margeta Milica A MA Shen Kang K
Science (New York, N.Y.) 20071001 5847
Neural circuits are assembled through the coordinated innervation of pre- and postsynaptic partners. We show that connectivity between two interneurons, AIY and RIA, in Caenorhabditis elegans is orchestrated by a pair of glial cells that express UNC-6 (netrin). In the postsynaptic neuron RIA, the netrin receptor UNC-40 (DCC, deleted in colorectal cancer) plays a conventional guidance role, directing outgrowth of the RIA process ventrally toward the glia. In the presynaptic neuron AIY, UNC-40 (DC ...[more]