Ontology highlight
ABSTRACT:
SUBMITTER: Cuff A
PROVIDER: S-EPMC2741583 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Cuff Alison A Redfern Oliver C OC Greene Lesley L Sillitoe Ian I Lewis Tony T Dibley Mark M Reid Adam A Pearl Frances F Dallman Tim T Todd Annabel A Garratt Richard R Thornton Janet J Orengo Christine C
Structure (London, England : 1993) 20090801 8
This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies (4% of all superfamilies) there is considerable structural divergence. While relatives share a similar fold in the evolutionary conserved core, diverse elaborations to this core can result in significant differences in the global structures. Applying similar protocols to examine ...[more]