Ontology highlight
ABSTRACT:
SUBMITTER: Marchetto MC
PROVIDER: S-EPMC2741600 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Marchetto Maria C N MC Yeo Gene W GW Kainohana Osamu O Marsala Martin M Gage Fred H FH Muotri Alysson R AR
PloS one 20090918 9
Genetic reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells or iPSCs) by over-expression of specific genes has been accomplished using mouse and human cells. However, it is still unclear how similar human iPSCs are to human Embryonic Stem Cells (hESCs). Here, we describe the transcriptional profile of human iPSCs generated without viral vectors or genomic insertions, revealing that these cells are in general similar to hESCs but with significant differences. For ...[more]