Fatty acid metabolism in the elderly: effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women.

ABSTRACT:

Context

Aging, low dehydroepiandrosterone (DHEA), and testosterone are associated with increased adiposity and metabolic risk. Treatment with these hormones may improve these abnormalities.

Objective

The objective of the study was to determine effects of aging, DHEA, or testosterone replacement on adiposity, meal fat partitioning, and postabsorptive lipolysis.

Design

This was a cross-sectional, 2-yr, double-blind, randomized, placebo-controlled trial.

Setting

The study was conducted in the general community.

Patients

Elderly women and men (>or=60 yr) with low DHEA sulfate (women and men) and bioavailable testosterone (men) concentrations and young adults.

Interventions

Thirty elderly women each received 50 mg DHEA or placebo daily for 2 yr. Thirty

SUBMITTER: Koutsari C 

PROVIDER: S-EPMC2741706 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature