Ontology highlight
ABSTRACT:
SUBMITTER: Elcheva I
PROVIDER: S-EPMC2742352 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20090701 2
miRNAs are largely known to base pair with the 3'UTR of target mRNAs, downregulating their stability and translation. mRNA of betaTrCP1 ubiquitin ligase is very unstable, but unlike the majority of mRNAs where 3'UTR determines the rate of mRNA turnover, betaTrCP1 mRNA contains cis-acting destabilizing elements within its coding region. Here we show that degradation of mRNA of betaTrCP1 is miRNA dependent and identify miR-183 as a microRNA that interacts with the coding region of betaTrCP1 mRNA. ...[more]