Ontology highlight
ABSTRACT:
SUBMITTER: Huarte E
PROVIDER: S-EPMC2742361 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Huarte Eduardo E Cubillos-Ruiz Juan R JR Nesbeth Yolanda C YC Scarlett Uciane K UK Martinez Diana G DG Buckanovich Ronald J RJ Benencia Fabian F Stan Radu V RV Keler Tibor T Sarobe Pablo P Sentman Charles L CL Conejo-Garcia Jose R JR
Cancer research 20080903 18
Dendritic cells (DC) and cytokines that expand myeloid progenitors are widely used to treat cancer. Here, we show that CD11c(+)DEC205(+) DCs coexpressing alpha-smooth muscle actin and VE-cadherin home to perivascular areas in the ovarian cancer microenvironment and are required for the maintenance of tumor vasculature. Consequently, depletion of DCs in mice bearing established ovarian cancer by targeting different specific markers significantly delays tumor growth and enhances the effect of stan ...[more]